Red Wine as an Aromatase Inhibitor: A Narrative Review

Finally, it is important to consult with a healthcare professional before starting any new medication, as they can provide guidance on the best course of action based on an individual’s specific needs and medical history. Statins could be used along with AIs to improve both lipid profiles and endothelial function. There is also a suggestion that long-term use of a lipophilic statin might reduce breast cancer risk (76), but results in case–control studies are mixed (77–79).

• The product contains several important ingredients such as DIM, Calcium-d-glucarate, and Chrysin, which work together to provide the best results.
• This slows down the conversion process, freeing up testosterone and balancing estrogen levels to keep hormone levels at normal healthy levels.
• Finally, it is important to consult with a healthcare professional before starting any new medication, as they can provide guidance on the best course of action based on an individual’s specific needs and medical history.
• Aromatase is the enzyme that catalyzes a key aromatization step in the synthesis of estrogen.

More tumour responses to aromatase inhibitors

It is packed with a premium blend of DIM, Chrysin, and Stinging Nettle Root that increases energy and maintains prostate health, which is vital for optimal living. Total GAINS is made in a state-of-the-art cGMP compliant facility in the USA and Steroids is meticulously tested for purity and potency. The product is backed by a 30-day Better Body Money Back Guarantee, ensuring customers can try it with confidence. One of the most common issues that people face is cystic acne that just won’t go away.

Unsubstituted flavanone (52), a natural product derivative, was found to range from having moderate aromatase inhibition 121, 122, 132, 133, 137 to being inactive 128 in microsomal biological evaluations. 7-Hydroxyflavanone (56) and 7-methoxyflavanone (58) were both found to be aromatase inhibitors in microsomes 133, 137, 138, with 7-hydroxyflavanone (56) exhibiting more potent activity than 7-methoxyflavanone (58). 7-Hydroxyflavanone (56) was also active in H295R cells but 7-methoxyflavanone was inactive 127. Hesperetin (5,7,3′-trihydroxy-4′-methoxyflavanone, 53) 121, 133 and eriodictyol (5,7,3′,4′-tetrahydroxyflavanone, 50) 133 were each tested twice in microsomal aromatase assays and found to be strongly active. 8-Prenylnaringenin (62, isolated from Humulus lupulus L.) was one of the most active natural product compounds tested for aromatase inhibition in both microsomes and cell assays 114, 139.

Reports of MSAEs linked to CDK4/6 inhibitors from the first quarter (Q1) of 2015 and 2023 Q4 were extracted from the FAERS. Descriptive analyses evaluated report frequencies over time and patient characteristics. Disproportionality analyses using reporting odds ratios (RORs) identified signals for specific musculoskeletal preferred terms (PTs).

I have a bachelor’s in criminal justice and business obtained through Alvernia University. When I am not focused on work or training, I enjoy watching films or reading about anything and everything. Do not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Please consult your healthcare provider with any questions or concerns you may have regarding your condition.

Red Wine as an Aromatase Inhibitor: A Narrative Review

Apart from the positive effects on the development of gynecomastia, the use of AIs in male patients with AEXS has been found to improve adult height, promote virilization and increase testicular volume (5, 7, 10, 12, 29). So far, anastrozole has been used in the majority of studies with patients with AEXS, while letrozole has been used in combination with growth hormone treatment in only one study (12). Both anastrozole and letrozole suppress estrogen production by 97-99% and are highly selective (4). In the current report, letrozole was selected due to its higher potency in inhibiting aromatase activity. Letrozole is, like anastrozole, rapidly absorbed, but has a longer half-life of 2 to 4 days, leading to higher plasma testosterone concentrations (4, 30).

Anastrozole can also undergo direct in vitro conjugation (24) without prior involvement of cytochrome P450 enzymes. In addition, anastrozole is also able to inhibit, in vitro, CYP1A2, 2C9, and 3A4 in human microsomes. However, this inhibition occurs to a much lesser extent than that described for aromatase, and the concentrations required for this purpose are not reached in the systemic circulation with the use of therapeutic doses (23). In males, androgens are produced both by the adrenal glands and the testes, whereas estrogen is mostly synthesized locally in peripheral tissues from the local aromatization of circulating androgens (2,3). Peripherally synthesized estrogen seems to have predominantly local effects (2,3,6).

2. Cardiovascular Events

Estrohalt is formulated without this ingredient, making it a safer and more effective option for those who want to reduce their estrogen levels. Chrysin Plus DIM Aromatase Inhibitor Cream is also a natural estrogen blocker for both men and women. The anti estrogen ingredients help the body process hormones correctly, promoting a healthier hormone balance. This is particularly important for women who may experience excessive estrogen levels during menopause. VMI Sports presents Arimidrol Hardening Compound, a natural estrogen blocker that helps in building muscle, boosting testosterone levels and inhibiting aromatase. The product comes in the form of 60 capsules that are specially formulated to improve muscle hardness, strength, mood, and overall performance.

Equol is also a superior antioxidant, having greater antioxidant capacity than vitamin C or vitamin E 49, and it has many other benefits covering cosmetics, prostate, and breast cancer along with several other health applications 48–52. Overall, the choice of aromatase inhibitor depends on individual patient factors, such as menopausal status, prior treatments, and other medical conditions. The product is a chemical and drug-free anabolic muscle accelerator with no artificial additives, making it a clean natural energy booster that increases strength, endurance, and stamina without any side effects.